Young-Hwa Goo, PhD
Areas of Study
Moledcular mechanism of metabolic diseases
- Baylor College of Medicine, Houston, TX2009Postdoctoral training
- Pohang University of Science and Technology, South Korea2004PhD
My lab is interested in finding the intertwined mechanism of lipid metabolism and inflammation, two major driving forces of atherogenesis. To achieve this goal, we have started studies on the mechanism of macrophage foam cell formation, the most abundant leukocytes in the atheroma. Using proteomics on isolated the fraction of lipid droplets (LD) in foam cells followed by a large-scale immunoprecipitation, we have delineated the networking of LD-associated proteins and identified new players that we further characterized and named. For unbiased functional analyses, we also use lipidomics and transcriptomics to draw interactive maps that may be regulated by LD-associated proteins. Based on these findings, we have generated knock-out, transgenic, and CRISPR-Cas9 edited knock-in mice to study the impacts of LD-associated proteins on atherosclerosis development and other metabolic diseases. Ultimately, to translate our findings to clinical application, we will discover small molecules involved in lipid metabolism and inflammation of macrophage foam cells. Therefore, we hope our study contributes to understanding the mechanism of lipid and inflammation induced metabolic diseases, the identification of therapeutic targets, and the discovery of small compounds to intervene in cardiovascular and other metabolic diseases.
Figueiro MG, Goo YH, Hogan R, Plitnick B, Lee JK, Jahangir K, Moulik M, Yechoor VK, Paul A. Light-Dark Patterns Mirroring Shift Work Accelerate Atherosclerosis and Promote Vulnerable Lesion Phenotypes. J Am Heart Assoc. 2021 Jan 6;:e018151. doi: 10.1161/JAHA.120.018151. [Epub ahead of print] PubMed PMID: 33401929.
Dubey R, Stivala CE, Nguyen HQ, Goo YH, Paul A, Carette JE, Trost BM, Rohatgi R. Lipid droplets can promote drug accumulation and activation. Nat Chem Biol. 2020 Feb;16(2):206-213. doi: 10.1038/s41589-019-0447-7. Epub 2020 Jan 13. PubMed PMID: 31932720; PubMed Central PMCID: PMC6989039.
Paul A, Lydic TA, Hogan R, Goo YH. Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells. Int J Mol Sci. 2019 Aug 2;20(15). doi: 10.3390/ijms20153784. PubMed PMID: 31382484; PubMed Central PMCID: PMC6695943.
Lydic TA, Goo YH. Lipidomics unveils the complexity of the lipidome in metabolic diseases. Clin Transl Med. 2018 Jan 26;7(1):4. doi: 10.1186/s40169-018-0182-9. Review. PubMed PMID: 29374337; PubMed Central PMCID: PMC5786598.
Goo YH, Son SH, Paul A. Lipid Droplet-Associated Hydrolase Promotes Lipid Droplet Fusion and Enhances ATGL Degradation and Triglyceride Accumulation. Sci Rep. 2017 Jun 2;7(1):2743. doi: 10.1038/s41598-017-02963-y. PubMed PMID: 28578400; PubMed Central PMCID: PMC5457427.
View Young-Hwa Goo's articles on the National Institute of Health's PubMed website.