Dana R. Crawford, PhD
Areas of Study
Redox, gene expression, and diet research
- Dartmouth College1983PhD
Dr. Crawford's laboratory is primarily involved in redox, gene expression, and diet research. He has identified a number of genes that are modulated by oxidative stress and is characterizing their function and possible clinical use in stress-related diseases and disorders. One of these genes, RCAN1 (ADAPT78), is important in regulating many calcium-dependent cellular functions, and we are currently assessing its role in immune system dysfunction, cancer, and brain (Down syndrome and Alzheimer's disease). A second set of oxidative stress-modulated genes that the lab studies are mitochondrial RNA and DNA. These polynucleotides are preferentially oxidized and degraded during stress, and we are now characterizing their involvement in inflammation. The laboratory is also involved in diet and nutrition as a healthy, low-cost and translational approach to treating multiple pathologies and conditions, a project we call dietary rational gene targeting. This novel approach uses healthy dietary agents to modulate key disorder causing genes, in turn providing potential complementary and alternative treatment therapies. Dr. Crawford also chairs the Capital Region Cancer Research (CRCR) group, an inter-institutional organization devoted to the cure of cancer.
Bagyi J, Sripada V, Aidone AM, Lin H-Y, Ruder EH, and Crawford DR. In press. Dietary rational gene targeting of redox-regulated genes. Free Radic. Biol. Med. Saxena AR, Ilic Z, Sripada V, and Crawford DR. 2020. Lower concentrations of curcumin inhibit Her2-Akt pathway components in human breast cancer cells, and other dietary botanicals potentiate this and lapatinib inhibition. Nutrition Research 78:93-104 Ilic Z, Saxena AR, Periasamy S, Crawford DR. 2019. Control (Native) and oxidized (DeMP) mitochondrial RNA are proinflammatory regulators in human. Free Radic Biol Med. 143:62-69. Crawford DR, Ilic Z, Guest I, Milne GL, Hayes JD, Sell S. 2017. Characterization of liver injury, oval cell proliferation and cholangiocarcinogenesis in glutathione S-transferase A3 knockout mice. Carcinogenesis. 38(7):717-727. Saxena AR, Gao LY, Srivatsa S, Bobersky EZ, Periasamy S, Hunt DT, Altman KE, and Crawford DR. 2017. Oxidized and degraded mitochondrial polynucleotides (DeMPs), especially RNA, are potent immunogenic regulators in primary mouse macrophages. Free Radic. Biol. Med. 104:371-379 View Dana R. Crawford's articles on the National Institute of Health's PubMed website.