Areas of Study
Cardiovascular Mechanisms of Diseases
Education
- University of Calgary, CanadaPhysiologyPhD
- University of Bordeaux, FrancePharmacologyDEA
- University of Bordeaux, FranceBiochemistryBS
Research
We study the basic science of how blood vessels and the heart work at the molecular level, laying the groundwork for new therapeutics for cardiovascular diseases.
The Jourd’heuil laboratory's overarching goal is to discover redox signaling mechanisms underlying cardiovascular diseases and to develop new therapeutic strategies that target these pathways.
Our laboratory has integrated unique expertise in redox biology, protein redox biochemistry, conditional targeting of redox proteins, lineage tracing, and genomics with specific attention to the contribution of vascular cells such smooth muscle cells and fibroblasts to cardiovascular disease.
Our laboratory collaborates with other initiatives at Albany Medical College and in the greater Capital Region that explore redox biology and nitric oxide (NO) physiology and pathophysiology in the context of neuropathies, cancer, asthma, and pulmonary diseases. We provide expertise in redox biology, NO metabolomics, and metabolic profiling to assist our collaborators and other investigators.
Publications
View David Jourd'heuil's articles on the National Institutes of Health's PubMed website.
Recent publications of interest
Frances Jourd'heuil, Clinton Mathai, Le Gia Cat Pham, Kurrim Gilliard, Joseph Balnis, Katherine A Overmyer, Joshua J Coon, Ariel Jaitovich, Benoit Boivin, and David Jourd'heuil. Cytoglobin scavenges hydrogen peroxide and regulates redox signals in the vasculature. Redox Biol. 2025 Jun; 83:103633. PMID:40252320.
Clinton Mathai, Frances Jourd’heuil, Le Gia Cat Pham, Kurrim Gilliard, Dennis Howard, Joseph Balnis, Ariel Jaitovich, Sridar V. Chittur, Mark Rilley, Ruben Peredo-Wende, Ibrahim Ammoura, Sandra J. Shin, Margarida Barroso, Jonathan Barra, Evgenia Shishkova, Joshua J. Coon, Reynold I. Lopez-Soler, and David Jourd'heuil. Regulation of DNA damage and transcriptional output in the vasculature through a cytoglobin-HMGB2 axis. Redox Biol. 2023 Sep; 65:102838. PMID: 37573836
Mathai C., Jourd’heuil F., Lopez-Soler R., and Jourd’heuil D. Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase. Redox Biol 2020 May; 32:101468. PMID: 32087552