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Sarah E McCallum , Ph.D.
Assistant Professor


1999 - Ph.D. from University of Pittsburgh

Research Interests


·        The identification and functional role of neuronal nicotinic receptors in substance abuse, neurodegenerative disease and other psychiatric conditions
·        The long-term regulation of nicotinic receptors by smoking

PubMed Publications

  1. McCallum SE, Parameswaran N, Bordia T, McIntosh JM, Grady SR, Quik M (2005). Decrease in alpha3*/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage. Mol Pharmacol, 68, 737-746.

  2. McCallum SE, Parameswaran N, Bordia T, Fan H, Tyndale RF, Langston JW, McIntosh JM, Quik M (2006) Increases in alpha4* but not alpha3*/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment. J Neurochem, 96, 1028-1041.

  3. McCallum SE, Parameswaran N, Perex XA, Bao S, McIntosh JM, Grady SR, Quik M (2006) Compensation in pre-synaptic dopaminergic function following nigrostriatal damage in primates. J Neurochem, 96, 960-972.

  4. McCallum SE, Collins AC, Paylor R, Marks MJ (2006) Deletion of the beta2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation. Psychopharmacol, 184, 314-327.

  5. Quik M, Chen L, Parameswaran, Xie X, Langston JW, McCallum SE (2006) Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned primates. J Neurosci, 26, 4681-4689.

  6. McCallum SE, Parameswaran N, Bordia T, Fan H, McIntosh JM, Quik M (2006) Differential regulation of mesolimbic alpha3*/alpha6beta2* and alpha4beta2* sites and function after long-term oral nicotine to monkeys. JPET, 318, 381-388.

  7. Quik M, Parameswaran N, McCallum SE, Bordia T, Bao S, McCormack A, Kim A, Tyndale RF, Langston JW, Di Monte DA (2006) Chronic oral nicotine protects against striatal degeneration in MPTP-treated primates. J Neurochem, 98, 1866-1875.

  8. Matta SG, Balfour DJ, Benowitz NL et al (2007) Guidelines on nicotine dose selection for in vivo research. Psychopharmacol, 190, 269-319.

  9. Brady AM, McCallum SE, Glick SD, O'Donnell P (2008) Enhanced methamphetamine self-administration in a neurodevelopmental model of schizophrenia. Psychopharmacol, 200, 205-215.

  10. McCallum SE, Glick SD (2009) 18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference. Neurosci Lett, 458, 57-59.

  11. Wu J, McCallum SE, Glick SD, Huang Y (2011) Inhibition of the mammalian target of rapamycin pathway by rapamycin blocks cocaine-induced locomotor sensitization. Neuroscience, 172, 104-109.

  12. Glick SD, Sell EM, McCallum SE, Maisonneuve IM (2011) Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on nicotine self-administration. Eur J Pharmacol, 669, 71-75.

  13. McCallum SE, Taraschenko OD, Hathaway ER, Vincent MY, Glick SD (2011) Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. Psychopharmacol, 215, 247-256.

  14. McCallum SE, Cowe MA, Lewis SW, Glick SD (2012) Alpha3beta4 nicotinic acetylcholine receptors in the medial habenula modulate the mesolimbic dopaminergic response to acute nicotine in vivo. Neuropharmacol, 63, 434-440.

  15. Li L, Jia K, Zhou X, McCallum SE, Hough LB, Ding X (2013) Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse. JPET, 347, 746-754.