INDIVIDUAL RESEARCHERYunfei Huang , MD , Ph.D
Education2000 - Ph.D from Emory University
1987 - MD from Nanjing Medical University
My laboratory is interested in understanding the signaling pathways that regulate cell growth and survival. Specifically, we are focusing on 1) The mammalian target of rapamycin pathway (mTOR), a critical signaling pathway in the development, differentiation and growth of the organism as well as in maintaining normal metabolic homeostasis; 2) The eIF5A hypusination, a polyamine based protein modification that modulates protein translation.
We also intend to understand how these signaling pathways are involved in pathophysiological conditions, particularly those related to neurological disorders.
Currently we have four areas of investigation:
- To delineate the molecular pathways by which the mTOR senses amino acids.
- To investigate the roles of mTOR pathway in epileptogenesis and drug addictions.
- To elucidate the biological action of eIF5A hypusination modification.
- To examine the role of hypusination pathway in neurodegenerative diseases and regeneration.
- Huang Y, Higginson DS, Hester L, Park MH, Snyder SH. Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Proceedings of the National Academy of Sciences, 104:4194-9, 2007.
- Huang Y, Kang BN, Tian J, Liu Y, Luo HR, Hester L, Snyder SH. The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Journal of Neuroscience, 27:449-58, 2007.
- Riccio A., Alvania R.S., Bonnie E. Lonze B.E., Taeho Kim T., Huang Y., Dawson T.M., Snyder S.H., and Ginty D.D. A novel neurotrophin signalling pathway controlling CREB activity in neurons. Molecular Cell, 21:283-94, 2006.
- Huang Y., and Snyder S.H. Nitrosylation and thiolylation. Encyclopedia of Genomics, Proteomics and Bioinformatics. John Wiley & Sons, Ltd. 2005.
- Huang Y., Man H.Y., Sekine-Aizawa Y., Han Y.F., Juluri K., Luo H., Cheah J., Lowenstein C., Huganir R. L., and Snyder S.H. S-nitrosylation of N-ethylmaleimide sensitive factor (NSF) mediates surface expression of AMPA receptors. Neuron 46(4):533-40, 2005.