James A. Bennett
Clinical Interests: Improving the diagnosis and treatment of cancer in the lung, breast and prostate. Research Interests: I am investigating the role of alpha-fetoprotein (AFP) and peptides derived from AFP in the regulation of endocrine cancer growth. We have shown that full-length AFP blocks the estrogen-stimulated growth of human breast cancer xenografts and the androgen-stimulated growth of human prostate cancer xenografts. The active site of AFP is located in Domain III (carboxyl end) of the molecule. We have synthesized a 34-amino-acid peptide (amino acids 447-480 of AFP) derived from AFP which retains the activity of the full-length molecule. We are currently synthesizing smaller portions of this peptide and implementing strategies for stabilizing this peptide so that it can be used for the treatment of steroid hormone-receptor-positive human endocrine cancers. We are also investigating the mechanism by which tumor growth inhibition is brought about by these peptides.
- Lin H-Y, Shih A, Davis FB, Tang H-Y, Martino LJ, Bennett JA, Davis PJ. Resveratrol-induced serine phosphorylation of p53 causes apoptosis in a mutant p53 prostate cancer cell line. J Urology, 2002; 168:748-755.
- Bennett JA, Mesfin FB, Andersen TT, Gierthy JF, Jacobson HI. A peptide derived from alpha-fetoprotein prevents the growth of estrogen-dependent human breast cancers sensitive and resistant to Tamoxifen. Proc Natl Acad Sci (US), 2002; 99:2211-2215.
- Mesfin FB, Andersen TT, Jacobson HI, Zhu SM, Bennett JA. Development of a synthetic cyclized peptide derived from alpha-fetoprotein that prevents the growth of human breast cancer. J Peptide Res, 2001; 58:246-256.
- Bennett JA, Zhu S, Pagano-Mirarchi A, Kellom TA, Jacobson HI. Alpha-fetoprotein derived from a human hepatoma prevents growth of estrogen-dependent human breast cancer xenografts. Clin Cancer Res, 1998; 4:2877-2884.
- Bennett JA, Semeniuk DJ, Jacobson HI, Murgita RA. Similarity between natural and recombinant human alpha-fetoprotein as inhibitors of estrogen-dependent breast cancer growth. Breast Cancer Res Treat, 1997; 45:169-179.