INDIVIDUAL RESEARCHERMichelle R. Lennartz , Ph.D.
Education1984 - Ph.D. from University of Michigan, Ann Arbor
Macrophages play a major role in health and disease. They recognize and destroy invading pathogens, contribute to chronic inflammatory diseases such arthritis and atherosclerosis, and are a reservoir for a select group of pathogens, including HIV, Mycobacterium tuberculosis (the causative agent of TB), and Francisella tularensis (a category A biodefense organism). Our research focuses on the cell biology of macrophages, using an IgG-phagocytosis system to model uptake and killing of pathogens as well as to study the underlying causes of the atherosclerotic plaque rupture that results in stroke and heart attack.
Infectious disease: We have identified protein kinase C-epsilon (PKC-ε) as an important signaling model in bacterial clearance. Mice lacking PKC-ε succumb to bacterial infections cleared by their wild type counterparts. We are using an animal model of sepsis (an abberant response to bacteria resulting in 18-50% mortality) to study how PKC-ε protects and understand why the knock-out animals are so sensitive to bacteria. The results may improve treatment options for sepsis in humans.
- Lennartz, M.R., A. Aggarwal, T.M. Michaud, P.J. Feustel, D.M. Jones, M.J. Brosnan, R.S. Keller, D.J. Loegering, and P.B. Kreienberg. Ligation of macrophage Fc? receptors recapitulates the gene expression pattern of vulnerable human carotid plaques. PLoS ONE 6:e21803, 2011.
- Loegering, D.J. and M.R. Lennartz. Protein kinase C and toll-like receptor signaling. Enzyme Res. 2011:537821, 2011.
- Harmon, E.Y., V. Fronhofer, R.S. Keller, P.J. Feustel, M.J. Brosnan, J.H. von der Thüsen, D.J. Loegering, and M.R. Lennartz. Ultrasound biomicroscopy for longitudinal studies of carotid plaque development in mice: Validation with histological endpoints. PLoS One 7:e29944, 2012.
- Wood, T.R., R.Y. Chow, C.M. Hanes, X. Zhang, K. Kashiwagi, Y. Shirai, M. Trebak, D.J. Loegering, N. Saito, and M.R. Lennartz. 2013. PKC-epsilon pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis. J. Leukoc. Biol. 94(1):109-122, 2013.