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INDIVIDUAL RESEARCHER

Lei Jin , M.Sc , Ph.D.
Assistant Professor
e-mail: JinL@mail.amc.edu

Phone: 518-262-0053

Education

2004 - Ph.D. from Tufts University
1998 - M.Sc from Fudan University


Current Research

My lab is interested in understanding the functions of STING (Stimulator of IFN genes, a.k.a. TMEM173, MPYS and MITA) in innate and adaptive immune response. Specially, we are focusing on three questions: 1) Understanding the in vivo functions and mechanisms of STING in host defense against bacterial infections; 2) Deciphering STING-mediated innate immune signaling; 3) Understanding the molecular and cellular mechanisms of STING-mediated mucosal vaccine adjuvant activity of cyclic dinucleotides.



Research Interests



Research Summary

 



PubMed Publications

  1. Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1B production.Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J. Nat Immunol. 2014 Jun;15(6):538-45


  2. Deletion of the cyclic di-AMP phosphodiesterase gene (cnpB) in Mycobacterium tuberculosis leads to reduced virulence in a mouse model of infection. Yang J, Bai Y, Zhang Y, Gabrielle VD, Jin L, Bai G. Mol Microbiol. 2014 May 7.


  3. MHC class II structural requirements for the association with Igalpha/beta, and signaling of calcium mobilization and cell death. Jin L, Stolpa JC, Young RM, Pugh-Bernard AE, Refaeli Y, Cambier JC. Immunol Lett. 2008 Mar 15;116(2):184-94.


  4. MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals. Jin L, Waterman PM, Jonscher KR, Short CM, Reisdorph NA, Cambier JC. Mol Cell Biol. 2008 Aug;28(16):5014-26.


  5. Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells. McKee AS, Burchill MA, Munks MW, Jin L, Kappler JW, Friedman RS, Jacobelli J, Marrack P. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31.


  6. STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration. Jin L, Getahun A, Knowles HM, Mogan J, Akerlund LJ, Packard TA, Perraud AL, Cambier JC. J Immunol. 2013 Mar 15;190(6):2835-43.


  7. Cellular reactive oxygen species inhibit MPYS induction of IFNbeta Jin L, Lenz LL, Cambier JC. PLoS One. 2010 Dec 10;5(12):e15142


  8. Identification and characterization of a loss-of-function human MPYS variant Jin L, Xu LG, Yang IV, Davidson EJ, Schwartz DA, Wurfel MM, Cambier JC. Genes Immun. 2011 Jun;12(4):263-9


  9. Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome. Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C. EMBO Rep. 2013 Oct;14(10):900-6.


  10. MPYS/STING-Mediated TNF-alpha, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3'-5')-Cyclic-Di-Guanosine-Monophosphate In Vivo. Blaauboer SM, Gabrielle VD, Jin L. J Immunol. 2014 Jan 1;192(1):492-502.


  11. VISA is required for B cell expression of TLR7. Xu LG, Jin L, Zhang BC, Akerlund LJ, Shu HB, Cambier JC. J Immunol. 2012 Jan 1;188(1):248-58


  12. MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP. Jin L, Hill KK, Filak H, Mogan J, Knowles H, Zhang B, Perraud AL, Cambier JC, Lenz LL. J Immunol. 2011 Sep 1;187(5):2595-601.