INDIVIDUAL RESEARCHERDamian S. Shin , M.Sc , Ph.D.
Education2009 - Toronto Western Hospital [Post Doc Fellowship]
2005 - Ph.D. from University of Toronto
1999 - M.Sc from University of Western Ontario
The overall goal of my lab is to elucidate the neuronal signaling and information processing of the basal ganglia at the cellular and network level as it pertains to normal brain function and dysfunction. Currently, an understanding of the basal ganglia’s role in motor allowance – whether for its initiation, coordination and/or execution has not been completely determined. To undertake this task my laboratory employs the whole-cell patch-clamp technique or field electrodes on brain slices, in the normal or parkinsonian state, oriented to contain a single or a group of brain regions of the basal ganglia. Furthermore, in order to gain insight into the network properties of the basal ganglia during normal and parkinsonian motor tasks, in vivo recordings in the freely moving animal will also be employed from various basal ganglia nuclei. We hope that the information we obtain from these experiments will develop treatment paradigms for ameliorating the symptoms of Parkinson’s disease. The specific research goals of my lab are outlined below:
Alexander Sutton: PhD candidate
Wilson Yu: PhD candidate
Katie Sheeran: PhD candidate
- Yu W, Calos M, Pilitsis J, Shin DS (2012). Deconstructing the neural and ionic involvement of seizure-like events in the striatal network. Neurobiology of Disease. Epub ahead of print.
- Pushparaj A, Hamani C, Yu W, Shin DS, Nobrega JN, Le Foll B (2012). Electrical stimulation of the insular region attenuates nicotine-taking and nicotine-seeking behaviors. Neuropsychopharmacology. Epub ahead of print.
- Sutton A, Yu WJ, Calos ME, Smith AB, Ramirez-Zamora A, Molho ES, Pilitsis JG, Brotchie JM, Shin DS (2012). Deep brain stimulation of the substantia nigra reticulata improves forelimb akinesia in the parkinsonian rat. Journal of Neurophysiology. Epub ahead of print.
- Sutton A, Yu WJ, Calos ME, Mueller LE, Berk M, Molho E, Brotchie JM, Carlen PL, Shin DS (2012). Elevated K+ provides an ionic mechanism for deep brain stimulation in the hemiparkinsonian rat. European Journal of Neuroscience. Epub ahead of print.
- Huang X, McMahon J, Yang J, Shin D, Huang Y (2012). Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats. Neuroscience. 219:33-47.
- Pamenter ME, Hogg DW, Ormond J, Shin DS, Woodin MA, Buck LT (2011). Endogenous GABA(A) and GABA(B) receptor-mediated electrical suppression is critical to neuronal anoxia tolerance. Proceedings of the National Academy of Sciences. 108(27):11274-9.
- Zhang ZJ, Koifman J, Shin DS, Ye H, Florez CM, Zhang L, Valiante TA, Carlen PL (2012). Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region. Journal of Neuroscience. 32(7):2499-512.
- Shin DS, Yu W, Sutton A, Calos M, Puil E, Carlen PL (2011). Isovaline, a rare amino acid, has anti-convulsant properties in two in vitro hippocampal seizure models by increasing interneuronal activity. Epilepsia. 52(11):2084-93.
- Shin DS, Yu W, Sutton A, Calos M, Carlen PL (2011). Elevated potassium elicits recurrent surges of large GABAA-receptor mediated post-synaptic currents in hippocampal CA3 pyramidal neurons. Journal of Neurophysiology. 105(3):1185-98.
- Shin DS, Yu W, Fawcett A, Carlen PL (2010). Characterizing the persistent CA3 interneuronal spiking activity in elevated extracellular potassium in the young rat hippocampus. Brain Research. 1331:39-50.
- Hamani C, Dubiela FP, Soares JCK, Shin D, Bittencourt S, Covolan L, Carlen P, Laxton AW, Hodaie M, Lozano AM, Mello LE, Oliveria MGM (2010). Anterior thalamus deep brain stimulation at high current impairs memory in rats. Experimental Neurology. 225:154-162.
- Shin DS, Carlen PL (2008). Enhancement of the hyperpolarization-activated channel mediates the high frequency stimulation and raised K+-induced depression of rat entopeduncular nucleus neuronal activity. Journal of Neurophysiology. 99(5):2203-2219.
- Derchansky M, Shokrollah J, Mamani M, Shin DS, Sik A, Carlen PL (2008). Transition to Seizure: A Switch from Phasic Dominant Inhibition to Dominant Excitation. Journal of Physiology (London). 586(2):477-494.
- Shin DS, Samoilova M, Cotic M, Zhang L, Brotchie JM, Carlen PL (2007). High frequency stimulation or raised K+ depress neuronal activity in the rat entopeduncular nucleus. Neuroscience. 149(1):68-86.
- Pamenter ME, Shin DS, Buck LT (2008). Adenosine mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortex. Brain Research. 1213:27-34.
- Wilkie MP, Pamenter ME, Alkabie S, Carapic D, Shin DS, Buck LT (2008). Evidence of Anoxia-Induced Channel Arrest in the Brain of the Goldfish (Carassius auratus). Comparative Biochemistry and Physiology. 148:355-362.
- Pamenter ME, Shin DS, Cooray M, Buck LT (2008). Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle. Journal of Physiology (London). 586(4):1043-1058.
- Pamenter ME, Shin DS, Buck LT (2008). AMPA receptors undergo channel arrest in the anoxic turtle cortex. American Journal of Physiology Regulatory and Integrative Comparative Physiology. 294(2):R606-R613.
- Shin DS, Wilkie MP, Pamenter ME, Buck LT (2005). Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex. Comparative Biochemistry & Physiology, Part A. 142(1):50-57.
- Shin DS, Buck LT (2003). Effect of anoxia and pharmacological anoxia on whole-cell NMDA receptor currents in cortical neurons from the western painted turtle. Physiological and Biochemical Zoology. 76(1):41-51.
- Shin DS, Ghai H, Cain S, Buck LT (2003). Gap junctions do not underlie changes in whole-cell conductance in anoxic turtle brain. Comparative Biochemistry and Physiology, Part A. 134(1):179-192.
- Buck LT, Shin DS (2002). The role of adenosine in the natural anoxia-tolerance of the freshwater turtle. Trends in Comparative Biochemistry & Physiology. 9:93-116.