INDIVIDUAL RESEARCHER

Yunfei Huang , MD , Ph.D
Assistant Professor
e-mail: huangy@mail.amc.edu

Phone: 518-262-5873

Education

1987 - MD from Nanjing Medical University
2000 - Ph.D from Emory University

My laboratory is interested in understanding the signaling pathways that regulate cell

growth and survival. Specifically, we are focusing on

the mammalian target of rapamycin pathway (mTOR), a critical signaling pathway in the development, differentiation and growth of the organism as well as in maintaining normal metabolic homeostasis;
eIF5A hypusination, a polyamine based protein modification that modulates protein translation.

We also intend to understand how these signaling

pathways are involved in pathophysiological conditions, particularly those related to

neurological disorders. Currently we have four areas of investigation:

To delineate the molecular pathways by which the mTOR senses amino acids.
To investigate the roles of mTOR pathway in epileptogenesis and drug addictions.
To elucidate the biological action of eIF5A hypusination modification.
To examine the role of hypusination pathway in neurodegenerative diseases and regeneration.