INDIVIDUAL RESEARCHERJiliang Zhou , Ph.D.
Education2002 - Ph.D. from Zhejiang University, China
Smooth muscle cells (SMCs) are important contractile components of cardiovascular, respiratory, genitourinary, and digestive systems. Fully differentiated or mature SMCs proliferate at an extremely low rate and are almost completely geared for contraction. Differentiated SMCs are characterized by the presence of a unique repertoire of contractile proteins. The expression of these marker proteins is markedly attenuated during the de-differentiation and proliferation of smooth muscle that occurs under many pathological conditions such as atherosclerosis, restenosis and asthma. The mechanisms that result in down-regulation of contractile proteins during phenotypic modulation of smooth muscle are poorly understood. Our long-term goal is to determine the molecular mechanisms that regulate the differentiation and development of smooth muscle cells. Particularly, we are interested in the transcriptional control of vascular smooth muscle differentiation and phenotypic modulation. We utilize a variety of approaches, with combinations of molecular, cellular techniques and animal model, including transgenic and knock-out mice, to investigate functions of related transcription factors in smooth muscle cells. Unraveling these mechanisms will be an important step towards better understanding, and ultimately designing therapeutic agents for treatment of congenital vascular defects and smooth muscle-related diseases.
- Wang X., Hu G., Courtney B.C., Harmon, E.Y., Keller R.S., Van De Water L., and Zhou J.. TGFB1I1, a novel marker for smooth muscle contractile phenotype, is regulated by SRF/myocardin protein. J. Biol. Chem., 2011, in press
- Zhou, J., Hu, G., Wang X.. Repression of smooth muscle differentiation by a novel high-mobility-group box containing protein, HMG2L1. J. Biol. Chem., 2010, 285(30): 23177-23185.
- Wang, X., Hu, G., Zhou, J.. Repression of versican expression by miR-143. J. Biol. Chem., 2010, 285(16): 11800-11809.
- Hu, G., Wang, X., Saunders, D., Henderson. M., Russell A., Herring, B.P., Zhou, J.. Modulation of myocardin function by the ubiquitin E3 ligase, UBR5. J. Biol. Chem., 2010, 285(16): 11800-11809
- Zhou, J., Zhang, M., Fang H., El-Mounayri, O., Rodenberg J., Imbalzano A., and Herring B.P. The SWI/SNF chromatin remodeling complex is essential for myocardin induced smooth muscle cell differentiation. Arteriosclerosis, Thrombosis, and Vascular Biology, 2009, 29(6): 921-928.