Rebecca S. Keller
University of Missouri-Columbia
The principle goal of the lab is to understand the role of integrins in survival of the cardiomyocyte. Specifically, we study how integrins respond to stress in a cardiomyocyte under different load conditions and how integrin signaling may relate to the altered ability of the myocyte to function appropriately. Answers to these questions are essential for understanding cardiomyopathies relating to volume and pressure stresses. We use adenoviral infection techniques to inhibit or activate signaling pathways and determine the effect of these pathways on cellular responses. Other techniques include western blot analysis, real-time quantitative RT-PCR,immunofluorescence, and survival assays.
- Lin Q, Keller RS, Weaver B, Zisman LS. Interaction of ACE2 and integrin beta1 in failing human heart. Biochim Biophys Acta 1689(3):175-8, 2004.
- Pfleiderer PJ, Lu KK, Crow MT, Keller RS, Singer HA. Modulation of vascular smooth muscle cell migration by calcium/calmodulin-dependent protein kinase II-delta 2. Am J Physiol 286(6):C1238-45, 2004.
- Valencik ML, Keller RS, Loftus JC, McDonald JA. A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes. J Card Fail 8(4):262-272, 2002.
- Keller RS, Shai S-Y, Babbit C, Pham CG, Solaro RJ, Loftus JC, Ross RS. Transgenic expression of autonomous b1 integrin cytoplasmic domains leads to abnormal cardiac function, fibrosis and perinatal lethality. Am J Pathol 158(3):1079-1090, 2001.
- Pham CG, Harpf AE, Keller RS, Vu HT, Shai S-Y, Loftus JC, Ross RS. The striated-muscle specific integrin b1D is involved in the cardiac myocyte hypertrophic response pathway. Am J Physiol 279:H2916-H2926, 2000.