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Electives |
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CBCR 602 |
Model Systems in Cell Biology (Spring)
Credits: 2
To be arranged
This course will survey the recent literature with yearly emphasis in a specific topic area and reflecting current trends in cell biology. Discussions will focus on certain model systems including: Tissue repair and remodeling; Tumor growth and metastasis; Inflammation and monocyte response; Cytoskeleton and cell function; Nuclear structure and gene expression; Cell growth and differentiation; Growth factor signaling. Basic knowledge of cell biology and biochemistry is required. CMB courses in Signal Transduction and Tissue Remodeling and Cell Motility are strongly recommended. The course will center around faculty-organized discussions and student presentations. Each student will be required to present papers from the current literature (to be selected by the Faculty Course Director) and lead a group discussion. Grades will reflect student performance as both discussion leader and participant. The subject covered in CMB602 will change during each year offered and will likely reflect the research interests of the Course Director. At the time of registration, students will be informed of the subject matter to be addressed and the name of the responsible faculty member. Exams will not be part of the grading system, however a paper may be required by particular faculty, and, if so, students will be made aware of this prior to registration. Evaluations of any such required paper will be a consideration in the final grade.
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BIO 539 |
Comparative Functional Genomics (Fall) *
Credits: 3
To be arranged
This graduate level course is required for students participating in the Functional Genomics training program. This course consists of several modules that represent an integrated, comprehensive review of concepts, goals and methods of genome analysis at several levels, encompassing both classical and molecular approaches. (1) Review of classical genetics: the basics of Mendelian inheritance, unusual genetic and epigenetic phenomena; (2) Review of molecular genetics: recombinant DNA technology; principles and mechanisms of gene expression: transcription and its regulation, posttranscriptional events, translational and posttranslational control; (3) Model organisms and model genomes (bacteria, yeast, Drosophila, C. elegans, zebrafish, Arabidopsis, mouse, human), life cycles, genome structure and peculiarities; (4) Comparative analyses: gene and protein families, phylogenetic reconstructions, computational support of the genome-wide scale sequence analysis; (5) Large scale genome analysis and genome sequencing: physical and genetic mapping, expressed sequence tags, large scale sequencing strategies; (6) Map based cloning and application to human genetic disease; and (7) Transgenic technologies: principles and applications.
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BIO 540 |
Principles of Bioinformatics (Spring) *
Credits: 3
Dr. George Berg
This course will provide hands-on training in methods of computer-assisted bioinformatics, with specific application to biological research. Topics include: data mining, sequence retrieval, DNA and protein sequence alignment, molecular evolution and phylogenetic analysis, population genetics and analysis of genetic variation within species, comparative genomics of model organisms, and computer-based visualization and analysis of macromolecular structures.
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BMS 601A |
Introduction to Biomedical Sciences (Fall)
Credits: 3
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BMS 601B |
Introduction to Biomedical Sciences (Spring)
Credits: 3
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BMS 665T |
Mammalian Genetics (Fall)
Credits: 1
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CS 601 |
Molecular Control of Vascular Cell Cytoskeletal Proteins (Fall)
Credits: 2
Dr. Harold Singer , Dr. Peter Vincent
This course addresses the actin cytoskeleton and actin-myosin interactions during smooth muscle contraction/relaxation and in endothelial cells during shape changes leading to altered vascular permeability. The signal transduction pathways responsible for regulating cytoskeletal interactions in these cells are compared. The course first focuses on the contractile and structural cytoskeleton in smooth muscle. This is followed by discussions of the regulation of actin-myosin interactions by kinases, phosphatases, and thin filament regulatory proteins during smooth muscle contraction. The focus of the course then shifts to non-muscle cells with emphasis on the regulation of endothelial cell shape. Topics of discussion with respect to non-muscle cells include: comparison of the cortical actin cytoskeleton versus stress fibers, the role of small GTPases, and regulation of actin assembly by thin filament binding proteins. Control of endothelial cell shape is discussed in the context of the association of cell-cell and cell-matrix junctions with the actin cytoskeleton. Classes combine didactic presentations and student-lead discussions of current publications. Grades for this course are based on the quality of the student-led discussions and on a paper to be handed in two weeks after the last lecture.
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CS 608 |
Cardiovascular Physiology (Spring)
Credits: 3
Dr. Daniel Loegering
This course provides a solid foundation in the basic physiology of the cardiovascular system. The fundamentals of cardiac mechanics, hemodynamics, electrocardiography, and cardiovascular reflexes are integrated into understanding the control of cardiac output and tissue blood flow. The importance of these parameters is illustrated by discussion of exercise and the pathophysiological changes associated with valve defects and heart failure. Classes consist of lectures, laboratories, clinical presentations, and problem-solving conferences. Grades for this course are based upon a final examination.
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CS 609 |
Respiratory and Renal Physiology (Spring)
Credits: 4
Dr. Donald Bell
This course provides a solid foundation in basic physiology of the respiratory and renal systems. Basic concepts in gas exchange, pulmonary mechanics, ion transport processes, and nephron function are integrated into understanding the control of breathing and acid-base disorders. Basic concepts are extended into understanding the pathophysiology of abnormalities in ventilation perfusion and tissue oxygen delivery. The multiple transport processes within the kidney and their control are used to gain an understanding of a number of fluid and electrolyte disorders. There is a special emphasis on the quantitative analysis of clinical problems. Course format: Classes consist of lectures, laboratories, clinical presentations, and problem solving conferences. Grades for this course are based upon a final examination.
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IMD 608 |
Immunology (Spring)
Credits: 3
Dr. James Drake
The course provides an introductory overview of immunology. Student evaluation will be based on exams and student presentations. Required of ALL IMD theme students. Taught every year.
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IMD 609 |
Microbial Disease (Spring)
Credits: 3
Dr. Lisa Petti , Dr. Jing-Ren Zhang ,
The course provides an introductory overview of immunology. Student evaluation will be based on exams. Required of all IMD theme students during their first year. Taught every year.
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NEU 607 |
Fundamentals of Pharmacology (Spring)
Credits: 2
Dr. Lindsay Hough
An introduction will be provided to the principles by which drugs and other bioactive substances are absorbed, distributed and metabolized and how they act on biological systems. Topics include drug-receptor interactions, drug-effector interactions and pharmacokinetics.
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NEU 608 |
Biostatistics (Spring)
Credits: 3
Dr. Jeffrey Carlson
This is a course in basic biostatistics, which includes lectures on the mathematics necessary to understand statistical analysis. Integral to the course are instructions for proper experimental design and the appropriate use of statistical tests.
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NEU 612 |
Developmental Neuroscience (Spring)
Credits: 2
Dr. Sally Temple , Dr. Tara Fletcher , Dr. Pamela Swiatek
This course focuses on cellular and molecular mechanisms underlying the development of the central and peripheral nervous system. Lecture topics include neural induction, histogenesis, neuron migration, axon guidance, synaptogenesis and apoptosis. Also included are lectures on the modification of synaptic connections in development and regeneration, coordination of neural development with organogenesis, and the use of genetically modified animal models to probe gene function. In addition, students read and discuss article representative of current research on each lecture topic.
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NEU 613 |
Receptor Pharmacology (Fall)
Credits: 2
Dr. Milt Teitler
The course will cover the molecular biology and pharmacology of receptors. Introductory material will include an in-depth approach to the molecular dynamics of the ligand-receptor interaction. This will be followed by lectures on the three major families of receptors: the G-protein-coupled receptors (GPCR), the tyrosine kinase receptors (TK), and the ligand-gated ion channel receptors. Graduate level biochemistry is a prerequisite.
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